Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.36 |
| ▸ | BACE2 | Q9Y5Z0 | 4/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2110303 | 1.00 | BACE1 (0.36) | BACE1BACE2KCNH2CYP2D6 | |
| SCHEMBL2108493 | 1.00 | BACE1 (0.36) | BACE1BACE2KCNH2CYP2D6 | |
| SCHEMBL2108109 | 1.00 | BACE1 (0.36) | BACE1BACE2KCNH2CYP2D6 | |
| SCHEMBL2108012 | 1.00 | BACE1 (0.36) | BACE1BACE2KCNH2CYP2D6 | |
| SCHEMBL2110418 | 0.91 | BACE1 (0.36) | BACE1BACE2KCNH2CYP2D6 | |
| SCHEMBL2108685 | 0.91 | BACE1 (0.36) | BACE1BACE2KCNH2CYP2D6 | |
| SCHEMBL2110416 | 0.91 | BACE1 (0.36) | BACE1BACE2KCNH2CYP2D6 | |
| SCHEMBL2109255 | 0.89 | BACE1 (0.35) | BACE1BACE2KCNH2CYP2D6 | |
| SCHEMBL2108021 | 0.89 | BACE1 (0.35) | BACE1BACE2KCNH2CYP2D6 | |
| SCHEMBL2107010 | 0.89 | BACE1 (0.35) | BACE1BACE2KCNH2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8158620-B2 | Fused aminodihydrothiazine derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-04-17 | — | — | US | disclosed |