SCHEMBL2108641

CC(C)(C)N(C(=O)O)C1=N[C@@]2(c3ccccc3F)CC[C@@H](O)C[C@H]2CS1.CC(C)(C)N(C(=O)O)C1=N[C@@]2(c3ccccc3F)CC[C@H](F)C[C@H]2CS1

nearest known ligand 0.36

Predicted protein targets (top 1)

	gene	UniProt	supporting neighbours	confidence
▸	BACE1	P56817	12/20	0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL2110301	1.00	BACE1 (0.36)	BACE1
SCHEMBL2108034	0.96	BACE1 (0.38)	BACE1
SCHEMBL2108032	0.96	BACE1 (0.38)	BACE1
SCHEMBL2108515	0.96	BACE1 (0.38)	BACE1
SCHEMBL2107019	0.96	BACE1 (0.38)	BACE1
SCHEMBL2106872	0.96	BACE1 (0.38)	BACE1
SCHEMBL2106876	0.96	BACE1 (0.38)	BACE1
SCHEMBL2109779	0.86	BACE1 (0.39)	BACE1
SCHEMBL2109401	0.86	BACE1 (0.39)	BACE1
SCHEMBL2109399	0.86	BACE1 (0.39)	BACE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-8158620-B2	Fused aminodihydrothiazine derivatives	EISAI R&D MANAGEMENT CO., LTD. (JP)	2012-04-17	—	—	US	disclosed