Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.56 |
| ▸ | MMP2 | P08253 | 3/20 | 0.30 |
| ▸ | MMP3 | P08254 | 3/20 | 0.30 |
| ▸ | MMP1 | P03956 | 2/20 | 0.30 |
| ▸ | MMP9 | P14780 | 1/20 | 0.30 |
| ▸ | MMP8 | P22894 | 1/20 | 0.30 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19282571 | 0.95 | TUBB1 (0.62) | TUBB1MMP2MMP3MMP1MMP9 | |
| SCHEMBL16176461 | 0.95 | TUBB1 (0.62) | TUBB1MMP2MMP3MMP1MMP9 | |
| SCHEMBL16176459 | 0.95 | TUBB1 (0.62) | TUBB1MMP2MMP3MMP1MMP9 | |
| SCHEMBL20723955 | 0.95 | TUBB1 (0.62) | TUBB1MMP2MMP3MMP1MMP9 | |
| SCHEMBL16176457 | 0.95 | TUBB1 (0.62) | TUBB1MMP2MMP3MMP1MMP9 | |
| SCHEMBL16176313 | 0.87 | TUBB1 (0.58) | TUBB1MMP2MMP3MMP1MMP9 | |
| SCHEMBL16176311 | 0.87 | TUBB1 (0.58) | TUBB1MMP2MMP3MMP1MMP9 | |
| SCHEMBL16176309 | 0.87 | TUBB1 (0.58) | TUBB1MMP2MMP3MMP1MMP9 | |
| SCHEMBL19282582 | 0.87 | TUBB1 (0.58) | TUBB1MMP2MMP3MMP1MMP9 | |
| SCHEMBL16183185 | 0.87 | TUBB1 (0.60) | TUBB1MMP2MMP3MMP1ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968440-B1 | CYTOTOXIC AND ANTI-MITOTIC COMPOUNDS, AND METHODS OF USING THE SAME | ZYMEWORKS INC (CA) | 2019-06-05 | — | — | EP | disclosed |