Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 14/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | SPR | P35270 | 1/20 | 0.33 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.33 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12127548 | 0.90 | PTGDR2 (0.35) | PTGDR2AURKAPDPK1AURKBPDE10A | |
| SCHEMBL21088821 | 0.88 | PTGDR2 (0.35) | PTGDR2AURKAPDPK1AURKBPDE10A | |
| SCHEMBL12127551 | 0.81 | PTGDR2 (0.33) | PTGDR2PDE10ASPRKDM4DPTGDR | |
| SCHEMBL12128309 | 0.80 | PTGDR2 (0.37) | PTGDR2 | |
| SCHEMBL12128307 | 0.79 | PTGDR2 (0.35) | PTGDR2 | |
| SCHEMBL12128741 | 0.79 | MAPT (0.33) | PTGDR2AURKAPDPK1AURKBSPR | |
| SCHEMBL12128311 | 0.79 | PTGDR2 (0.35) | PTGDR2 | |
| SCHEMBL12128292 | 0.79 | APP (0.35) | PTGDR2 | |
| SCHEMBL12127660 | 0.78 | PTGDR2 (0.35) | PTGDR2 | |
| SCHEMBL12128729 | 0.78 | NPC1 (0.38) | PTGDR2AURKAPDPK1AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2558446-B1 | NOVEL COMPOUNDS FOR THE TREATMENT OF DISEASES ASSOCIATED WITH AMYLOID OR AMYLOID-LIKE PROTEINS | AC IMMUNE SA (CH) | 2019-06-12 | — | — | EP | disclosed |