Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 8/20 | 0.75 |
| ▸ | HTR1D | P28221 | 9/20 | 0.46 |
| ▸ | HTR1B | P28222 | 8/20 | 0.46 |
| ▸ | HTR1F | P30939 | 7/20 | 0.46 |
| ▸ | HTR1A | P08908 | 6/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12285936 | 0.87 | APP (0.74) | APPHTR1DHTR1BHTR1FHTR1A | |
| SCHEMBL12128866 | 0.87 | APP (0.81) | APP | |
| SCHEMBL12129574 | 0.86 | APP (1.00) | APPHTR1F | |
| SCHEMBL17805809 | 0.85 | APP (0.75) | APPCYP3A4CYP2D6 | |
| SCHEMBL21089219 | 0.83 | APP (0.54) | APPHTR1DHTR1BHTR1FHTR1A | |
| SCHEMBL12128962 | 0.83 | APP (0.69) | APPHTR1DHTR1BHTR1FHTR1A | |
| SCHEMBL17805808 | 0.82 | APP (0.53) | APPHTR1DHTR1BHTR1FHTR1A | |
| SCHEMBL21088220 | 0.82 | APP (0.84) | APPHTR1DHTR1BHTR1FHTR1A | |
| SCHEMBL12128821 | 0.82 | APP (1.00) | APPHTR1DHTR1BHTR1FHTR1A | |
| SCHEMBL17806042 | 0.82 | APP (0.72) | APPHTR1DHTR1BHTR1FHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2558446-B1 | NOVEL COMPOUNDS FOR THE TREATMENT OF DISEASES ASSOCIATED WITH AMYLOID OR AMYLOID-LIKE PROTEINS | AC IMMUNE SA (CH) | 2019-06-12 | — | — | EP | disclosed |