Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCKR | Q14397 | 10/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | GCK | P35557 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12089040 | 0.84 | GCKR (0.51) | GCKRPKMGCKLMNAMAPT | |
| SCHEMBL16686 | 0.83 | GCKR (0.57) | GCKRGCK | |
| SCHEMBL17956 | 0.83 | GCKR (0.57) | GCKRGCK | |
| SCHEMBL12078829 | 0.83 | GCKR (0.57) | GCKRGCK | |
| SCHEMBL16985 | 0.81 | GCKR (0.72) | GCKRGCK | |
| SCHEMBL17577 | 0.80 | GCKR (0.44) | GCKRPKMLMNAMAPTSMN1; SMN2 | |
| SCHEMBL23880 | 0.78 | GCKR (0.50) | GCKRGCK | |
| SCHEMBL17456 | 0.70 | GCKR (0.63) | GCKRGCK | |
| SCHEMBL16197 | 0.70 | GCKR (0.62) | GCKRGCK | |
| SCHEMBL16425 | 0.70 | GCKR (0.62) | GCKRGCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609081-A1 | SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | Amgen Inc. (US) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012027261-A1 | SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | AMGEN INC. (US) | 2012-03-01 | — | — | WO | disclosed |