Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 16/20 | 0.59 |
| ▸ | BACE2 | Q9Y5Z0 | 11/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2109574 | 1.00 | BACE1 (0.59) | BACE1BACE2KCNH2CYP2D6 | |
| SCHEMBL2620158 | 1.00 | BACE1 (0.59) | BACE1BACE2KCNH2CYP2D6 | |
| SCHEMBL2106984 | 0.90 | BACE1 (0.58) | BACE1BACE2KCNH2CYP2D6 | |
| SCHEMBL2108633 | 0.89 | BACE1 (0.69) | BACE1BACE2KCNH2 | |
| SCHEMBL2108096 | 0.89 | BACE1 (0.69) | BACE1BACE2KCNH2CYP2D6 | |
| SCHEMBL8030245 | 0.89 | BACE1 (0.64) | BACE1BACE2KCNH2CYP2D6 | |
| SCHEMBL2620152 | 0.88 | BACE1 (0.73) | BACE1BACE2KCNH2CYP2D6 | |
| SCHEMBL2931868 | 0.88 | BACE1 (0.73) | BACE1BACE2KCNH2CYP2D6 | |
| SCHEMBL2108207 | 0.86 | BACE1 (0.78) | BACE1BACE2KCNH2 | |
| SCHEMBL2109605 | 0.85 | BACE1 (0.67) | BACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2233474-B1 | CONDENSED AMINODIHYDROTHIAZINE DERIVATIVE | EISAI R&D MAN CO LTD (JP) | 2015-08-05 | — | — | EP | disclosed |
| US-8158620-B2 | Fused aminodihydrothiazine derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-04-17 | — | — | US | disclosed |