Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 6/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | CHUK | O15111 | 2/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.31 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21096677 | 0.89 | MAP3K14 (0.39) | MAP3K14DYRK1AMAPKAPK2ADORA2AADORA1 | |
| SCHEMBL21096568 | 0.83 | MAP3K14 (0.61) | MAP3K14CHUK | |
| SCHEMBL16205375 | 0.82 | MAP3K14 (0.44) | MAP3K14DYRK1AMAPKAPK2CHUKPDK1 | |
| SCHEMBL19626703 | 0.82 | MAP3K14 (0.64) | MAP3K14DYRK1AMAPKAPK2CHUKPDK1 | |
| SCHEMBL16205373 | 0.81 | MAP3K14 (0.43) | MAP3K14DYRK1AMAPKAPK2CHUKPDK1 | |
| SCHEMBL16205694 | 0.78 | DYRK1A (0.67) | MAP3K14DYRK1AMAPKAPK2CHUKGSK3B | |
| SCHEMBL16205374 | 0.76 | DYRK1A (0.48) | MAP3K14DYRK1AMAPKAPK2CHUKGSK3B | |
| SCHEMBL18828067 | 0.76 | DYRK1A (0.50) | MAP3K14DYRK1AMAPKAPK2CHUKPDK1 | |
| SCHEMBL21096536 | 0.76 | MAP3K14 (0.34) | MAP3K14ADORA2AADORA1 | |
| SCHEMBL16205695 | 0.75 | DYRK1A (0.49) | MAP3K14DYRK1AMAPKAPK2CHUKPDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10323045-B2 | Thienopyrimidine derivatives as NIK inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2019-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10323045-B2 | Thienopyrimidine derivatives as NIK inhibitors | MAP3K14, MAP3K15, MAP3K12 | MAP3K14 1/4885DYRK1A 955/4885MAPKAPK2 36/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.