Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 12/20 | 0.47 |
| ▸ | MAP3K20 | Q9NYL2 | 11/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | FRK | P42685 | 1/20 | 0.42 |
| ▸ | SIK1 | P57059 | 1/20 | 0.42 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | SRMS | Q9H3Y6 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21047291 | 0.82 | BRAF (0.68) | BRAFMAP3K20KITFRKSIK1 | |
| SCHEMBL21096946 | 0.73 | BRAF (0.45) | BRAFMAP3K20KITFRKSIK1 | |
| SCHEMBL21046769 | 0.72 | BRAF (0.77) | BRAFMAP3K20 | |
| SCHEMBL21046814 | 0.71 | BRAF (0.73) | BRAFMAP3K20KITFRKSIK1 | |
| SCHEMBL21096463 | 0.70 | BRAF (0.54) | BRAFMAP3K20KITFRKSIK1 | |
| SCHEMBL28074823 | 0.68 | MAP3K20 (0.60) | BRAFMAP3K20KITFRKSIK1 | |
| SCHEMBL19872610 | 0.67 | BRAF (0.50) | BRAFMAP3K20 | |
| SCHEMBL21096217 | 0.67 | BRAF (0.46) | BRAFMAP3K20 | |
| SCHEMBL21096938 | 0.67 | BRAF (0.66) | BRAFMAP3K20 | |
| SCHEMBL21096468 | 0.66 | BRAF (0.46) | BRAFMAP3K20 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3498693-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2019-06-19 | — | — | EP | disclosed |