Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 20/20 | 0.82 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.72 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.62 |
| ▸ | PIK3CB | P42338 | 10/20 | 0.62 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.62 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2110313 | 0.92 | PIK3CD (0.83) | PIK3CDCYP3A4PIK3CAPIK3CBPIK3CG | |
| SCHEMBL2110747 | 0.90 | PIK3CD (1.00) | PIK3CDCYP3A4PIK3CAPIK3CBPIK3CG | |
| SCHEMBL2673359 | 0.89 | PIK3CD (0.83) | PIK3CDCYP3A4PIK3CAPIK3CBPIK3CG | |
| SCHEMBL2674019 | 0.87 | PIK3CD (0.83) | PIK3CDCYP3A4PIK3CAPIK3CBPIK3CG | |
| SCHEMBL2111002 | 0.86 | PIK3CD (0.78) | PIK3CDCYP3A4PIK3CAPIK3CBPIK3CG | |
| SCHEMBL3622849 | 0.85 | PIK3CD (0.81) | PIK3CDCYP3A4PIK3CAPIK3CBPIK3CG | |
| SCHEMBL2675602 | 0.85 | PIK3CD (0.84) | PIK3CDCYP3A4PIK3CAPIK3CBPIK3CG | |
| SCHEMBL3612366 | 0.84 | PIK3CD (1.00) | PIK3CDCYP3A4PIK3CAPIK3CBPIK3CG | |
| SCHEMBL2674265 | 0.83 | PIK3CD (0.79) | PIK3CDCYP3A4PIK3CAPIK3CBPIK3CG | |
| SCHEMBL393580 | 0.83 | PIK3CD (1.00) | PIK3CDCYP3A4PIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100305084-A1 | BICYCLIC INDOLE-PYRIMIDINE PI3K INHIBITOR COMPOUNDS SELECTIVE FOR P110 DELTA, AND METHODS OF USE | HOFFMAN-LA ROCHE INC. | 2010-12-02 | — | — | US | claimed |
| US-8158625-B2 | Bicyclic indole-pyrimidine PI3K inhibitor compounds selective for P110 delta, and methods of use | GENENTECH, INC. (US) | 2012-04-17 | — | — | US | disclosed |
| US-8158625-B2 | Bicyclic indole-pyrimidine PI3K inhibitor compounds selective for P110 delta, and methods of use | GENENTECH, INC. (US) | 2012-04-17 | — | — | US | disclosed |
| US-8158625-B2 | Bicyclic indole-pyrimidine PI3K inhibitor compounds selective for P110 delta, and methods of use | GENENTECH, INC. (US) | 2012-04-17 | — | — | US | disclosed |
| WO-2010136491-A1 | BICYCLIC INDOLE-PYRIMIDINE PI3K INHIBITOR COMPOUNDS SELECTIVE FOR P110 DELTA, AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2010-12-02 | — | — | WO | disclosed |
| US-20100305084-A1 | BICYCLIC INDOLE-PYRIMIDINE PI3K INHIBITOR COMPOUNDS SELECTIVE FOR P110 DELTA, AND METHODS OF USE | HOFFMAN-LA ROCHE INC. | 2010-12-02 | — | — | US | disclosed |
| US-20100305084-A1 | BICYCLIC INDOLE-PYRIMIDINE PI3K INHIBITOR COMPOUNDS SELECTIVE FOR P110 DELTA, AND METHODS OF USE | HOFFMAN-LA ROCHE INC. | 2010-12-02 | — | — | US | disclosed |
| US-20100305084-A1 | BICYCLIC INDOLE-PYRIMIDINE PI3K INHIBITOR COMPOUNDS SELECTIVE FOR P110 DELTA, AND METHODS OF USE | HOFFMAN-LA ROCHE INC. | 2010-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305084-A1 | BICYCLIC INDOLE-PYRIMIDINE PI3K INHIBITOR COMPOUNDS SELECTIVE FOR P110 DELTA, AND METHODS OF USE | PI4K2B, PIK3CA, PIK3R2 | PIK3CD 4/4885CYP3A4 1910/4885PIK3CA 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.