Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | GRK2 | P25098 | 3/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 7/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21098772 | 0.96 | BRD4 (0.39) | KMT2AGAALMNAGRK2ROCK2 | |
| SCHEMBL21098936 | 0.93 | KMT2A (0.40) | KMT2AGAALMNAGRK2ROCK2 | |
| SCHEMBL22802047 | 0.83 | MAPT (0.46) | KMT2AGAALMNAGRK2ROCK2 | |
| SCHEMBL22802046 | 0.83 | MAPT (0.46) | KMT2AGAALMNAGRK2ROCK2 | |
| SCHEMBL21098730 | 0.83 | MAPT (0.46) | KMT2AGAALMNAGRK2ROCK2 | |
| SCHEMBL21052018 | 0.81 | MAPT (0.44) | KMT2AGAALMNAGRK2ROCK2 | |
| SCHEMBL21052015 | 0.81 | MAPT (0.44) | KMT2AGAALMNAGRK2ROCK2 | |
| SCHEMBL21098753 | 0.81 | MAPT (0.44) | KMT2AGAALMNAGRK2ROCK2 | |
| SCHEMBL21098749 | 0.80 | SMN1; SMN2 (0.42) | KMT2AGAALMNAGRK2ROCK2 | |
| SCHEMBL21052174 | 0.80 | SMN1; SMN2 (0.42) | KMT2AGAALMNAGRK2ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019109188-A1 | ACYL HYDRAZONE LINKERS, METHODS AND USES THEREOF | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2019-06-13 | — | — | WO | disclosed |