Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 6/20 | 0.60 |
| ▸ | TNF | P01375 | 4/20 | 0.41 |
| ▸ | LITAF | Q99732 | 4/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21050967 | 1.00 | KRAS (0.60) | KRASTNFLITAFHDAC6GPR119 | |
| SCHEMBL21099218 | 0.91 | KRAS (0.59) | KRASTNFLITAFHDAC6GPR119 | |
| SCHEMBL21050827 | 0.91 | KRAS (0.64) | KRAS | |
| SCHEMBL21099311 | 0.89 | KRAS (0.57) | KRASTNFLITAFHDAC6GPR119 | |
| SCHEMBL21099333 | 0.88 | KRAS (0.78) | KRASTNFLITAFHDAC6GPR119 | |
| SCHEMBL21099629 | 0.88 | KRAS (0.71) | KRASTNFLITAFHDAC6GPR119 | |
| SCHEMBL21137332 | 0.87 | KRAS (0.55) | KRASTNFLITAFHDAC6MAPT | |
| SCHEMBL21100008 | 0.86 | KRAS (0.65) | KRASTNFLITAFHDAC6GPR119 | |
| SCHEMBL21099304 | 0.85 | KRAS (0.55) | KRAS | |
| SCHEMBL21099287 | 0.83 | KRAS (0.55) | KRASTNFLITAFHDAC6GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190177338-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2019-06-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190177338-A1 | CHEMICAL COMPOUNDS | MKI67, CCNI, MCL1 | KRAS 272/4885TNF 2176/4885LITAF 995/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.