Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 16/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21050857 | 0.93 | KRAS (0.69) | KRAS | |
| SCHEMBL21136886 | 0.93 | KRAS (0.69) | KRAS | |
| SCHEMBL21050854 | 0.93 | KRAS (0.69) | KRAS | |
| SCHEMBL21050708 | 0.90 | KRAS (0.55) | KRASCYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL21050863 | 0.79 | KRAS (0.53) | KRAS | |
| SCHEMBL21050801 | 0.78 | KRAS (0.53) | KRAS | |
| SCHEMBL21099632 | 0.77 | KRAS (0.53) | KRAS | |
| SCHEMBL21050884 | 0.76 | KRAS (0.85) | KRAS | |
| SCHEMBL21050813 | 0.76 | KRAS (0.85) | KRAS | |
| SCHEMBL21824677 | 0.75 | KRAS (0.49) | KRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190177338-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2019-06-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190177338-A1 | CHEMICAL COMPOUNDS | MKI67, CCNI, MCL1 | KRAS 272/4885CYP2D6 166/4885SLC6A2 2424/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.