Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.56 |
| ▸ | BRD4 | O60885 | 3/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | EGFR | P00533 | 4/20 | 0.50 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.48 |
| ▸ | CCNK | O75909 | 2/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.48 |
| ▸ | CDK2 | P24941 | 2/20 | 0.48 |
| ▸ | CCND3 | P30281 | 2/20 | 0.48 |
| ▸ | CDK9 | P50750 | 2/20 | 0.48 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.47 |
| ▸ | BTK | Q06187 | 2/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21099572 | 0.87 | IRAK4 (0.56) | IRAK4BRD4JAK2EGFRALK | |
| SCHEMBL21099509 | 0.86 | ALK (0.58) | JAK2EGFRALKPTK2MAP3K7 | |
| SCHEMBL22807398 | 0.84 | IRAK4 (0.60) | IRAK4BRD4JAK2EGFRALK | |
| SCHEMBL21100225 | 0.82 | PTK2 (0.56) | IRAK4BRD4JAK2EGFRALK | |
| SCHEMBL22807484 | 0.80 | SRC (0.70) | EGFRADRA2ABTKABCB11ESR1 | |
| SCHEMBL21099556 | 0.80 | IRAK4 (0.56) | IRAK4BRD4JAK2EGFRALK | |
| SCHEMBL19867214 | 0.79 | PTK2 (0.59) | IRAK4BRD4JAK2EGFRADRA2A | |
| SCHEMBL19867381 | 0.79 | PTK2 (0.56) | IRAK4BRD4JAK2EGFRALK | |
| SCHEMBL19867185 | 0.79 | ALK (0.63) | IRAK4BRD4JAK2EGFRALK | |
| SCHEMBL21099830 | 0.77 | ALK (0.71) | EGFRALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3498716-A1 | THIENOPYRIMIDINE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND APPLICATIONS | Hongyun Biotech Co., Ltd. (CN) | 2019-06-19 | — | — | EP | disclosed |