Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 7/20 | 0.70 |
| ▸ | PIK3CA | P42336 | 12/20 | 0.65 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.65 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.65 |
| ▸ | APAF1 | O14727 | 1/20 | 0.43 |
| ▸ | CDC25B | P30305 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | PRKDC | P78527 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29561311 | 0.84 | PIK3CA (0.81) | PIK3CGPIK3CAPIK3CDPIK3CBAPAF1 | |
| SCHEMBL3194294 | 0.84 | PIK3CA (0.81) | PIK3CGPIK3CAPIK3CDPIK3CBAPAF1 | |
| SCHEMBL4807667 | 0.82 | PIK3CG (1.00) | PIK3CGPIK3CAPIK3CDPIK3CBAPAF1 | |
| SCHEMBL4412270 | 0.82 | PIK3CG (0.83) | PIK3CGPIK3CAPIK3CDPIK3CBAPAF1 | |
| SCHEMBL4283911 | 0.80 | PIK3CG (0.66) | PIK3CGPIK3CAPIK3CDPIK3CBAPAF1 | |
| SCHEMBL4808558 | 0.79 | PIK3CG (0.82) | PIK3CGPIK3CAPIK3CDPIK3CBAPAF1 | |
| SCHEMBL4413439 | 0.79 | PIK3CA (1.00) | PIK3CGPIK3CAPIK3CDPIK3CBAPAF1 | |
| SCHEMBL30531414 | 0.79 | PIK3CA (1.00) | PIK3CGPIK3CAPIK3CDPIK3CBAPAF1 | |
| SCHEMBL4807074 | 0.78 | PIK3CG (0.74) | PIK3CGPIK3CAPIK3CDPIK3CBAPAF1 | |
| SCHEMBL909580 | 0.78 | PIK3CG (1.00) | PIK3CGPIK3CAPIK3CDPIK3CBAPAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2551270-B1 | PYRAZOLOPYRIMIDINE DERIVATIVES FOR USE AS PI3 KINASE ANTAGONISTS | UNIV CALIFORNIA (US) | 2019-06-12 | — | — | EP | disclosed |