Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TYR | P14679 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28599305 | 0.85 | SLC6A4 (0.42) | NPC1RAB9ATP53MAPK1POLB | |
| SCHEMBL21205123 | 0.81 | MAPT (0.36) | NPC1RAB9ATP53SMN1; SMN2MAPT | |
| SCHEMBL28094009 | 0.77 | TYR (0.48) | NPC1RAB9ATP53MAPK1POLB | |
| SCHEMBL12602014 | 0.76 | TYR (0.44) | NPC1RAB9ATP53MAPK1POLB | |
| SCHEMBL630179 | 0.75 | TAAR1 (0.61) | NPC1RAB9ATP53MAPK1POLB | |
| SCHEMBL8497595 | 0.75 | TYR (0.39) | NPC1RAB9ATP53TYRMAPT | |
| SCHEMBL9478827 | 0.73 | TYR (0.46) | NPC1RAB9ATP53MAPK1POLB | |
| SCHEMBL28416322 | 0.73 | TYR (0.46) | NPC1RAB9ATP53MAPK1POLB | |
| SCHEMBL24376119 | 0.72 | TYR (0.40) | NPC1RAB9ATP53MAPK1POLB | |
| SCHEMBL21507864 | 0.72 | TYR (0.48) | NPC1RAB9ATP53MAPK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2551270-B1 | PYRAZOLOPYRIMIDINE DERIVATIVES FOR USE AS PI3 KINASE ANTAGONISTS | UNIV CALIFORNIA (US) | 2019-06-12 | — | — | EP | disclosed |