Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 17/20 | 0.62 |
| ▸ | INSR | P06213 | 15/20 | 0.62 |
| ▸ | IGF1R | P08069 | 15/20 | 0.62 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.59 |
| ▸ | EGFR | P00533 | 3/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | STK10 | O94804 | 1/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.56 |
| ▸ | SLC34A2 | O95436 | 1/20 | 0.56 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | CD74 | P04233 | 1/20 | 0.56 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | FYN | P06241 | 1/20 | 0.56 |
| ▸ | FES | P07332 | 1/20 | 0.56 |
| ▸ | CSF1R | P07333 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21099579 | 0.95 | ALK (0.59) | ALKINSRIGF1RPTK2EGFR | |
| SCHEMBL21099507 | 0.94 | ALK (0.59) | ALKINSRIGF1RPTK2EGFR | |
| SCHEMBL21099821 | 0.92 | ALK (0.60) | ALKINSRIGF1RPTK2EGFR | |
| SCHEMBL21099624 | 0.89 | ALK (0.73) | ALKINSRIGF1REGFRAURKA | |
| SCHEMBL21099421 | 0.88 | ALK (0.63) | ALKINSRIGF1RPTK2EGFR | |
| SCHEMBL19867180 | 0.87 | ALK (0.75) | ALKINSRIGF1RPTK2EGFR | |
| SCHEMBL21149605 | 0.86 | ALK (0.77) | ALKINSRIGF1RPTK2EGFR | |
| SCHEMBL21099882 | 0.86 | ALK (0.66) | ALKINSRIGF1RPTK2EGFR | |
| SCHEMBL21150067 | 0.86 | EGFR (0.75) | ALKINSRIGF1RPTK2EGFR | |
| SCHEMBL21099509 | 0.86 | ALK (0.58) | ALKINSRIGF1RPTK2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3498716-A1 | THIENOPYRIMIDINE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND APPLICATIONS | Hongyun Biotech Co., Ltd. (CN) | 2019-06-19 | — | — | EP | disclosed |