Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | KDM1A | O60341 | 18/20 | 0.61 |
| ▸ | MAOB | P27338 | 3/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.56 |
| ▸ | DRD2 | P14416 | 1/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.55 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12813366 | 1.00 | KDM4E (0.62) | KDM4EPKMKDM1AMAOBHDAC6 | |
| SCHEMBL21101170 | 1.00 | KDM4E (0.62) | KDM4EPKMKDM1AMAOBHDAC6 | |
| SCHEMBL12813368 | 1.00 | KDM4E (0.62) | KDM4EPKMKDM1AMAOBHDAC6 | |
| SCHEMBL19513593 | 1.00 | KDM4E (0.62) | KDM4EPKMKDM1AMAOBHDAC6 | |
| SCHEMBL12965568 | 1.00 | KDM4E (0.62) | KDM4EPKMKDM1AMAOBHDAC6 | |
| SCHEMBL12813626 | 1.00 | KDM4E (0.62) | KDM4EPKMKDM1AMAOBHDAC6 | |
| SCHEMBL12965573 | 0.96 | KDM4E (0.58) | KDM4EPKMKDM1AMAOBHDAC6 | |
| SCHEMBL15411012 | 0.96 | KDM4E (0.58) | KDM4EPKMKDM1AMAOBHDAC6 | |
| SCHEMBL15411011 | 0.96 | KDM4E (0.58) | KDM4EPKMKDM1AMAOBHDAC6 | |
| SCHEMBL15425023 | 0.96 | KDM4E (0.58) | KDM4EPKMKDM1AMAOBHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2688568-B1 | CYCLOPROPYLAMINES AS LSD1 INHIBITORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2019-06-19 | — | — | EP | disclosed |