Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 10/20 | 0.53 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.32 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10277559 | 0.85 | PDE10A (0.52) | PDE10ATLR7NPC1RAB9ATP53 | |
| SCHEMBL28454970 | 0.76 | PDE10A (0.43) | PDE10AMAPTNPC1GAADHFR | |
| SCHEMBL27940721 | 0.73 | PDE10A (0.41) | PDE10AMAPTRAB9AGAA | |
| SCHEMBL10277451 | 0.72 | PDE10A (0.41) | PDE10AMAPTNPC1RAB9AGAA | |
| SCHEMBL22844082 | 0.71 | ADORA2A (0.35) | TLR7 | |
| SCHEMBL10309446 | 0.71 | PDE10A (1.00) | PDE10ATLR7 | |
| SCHEMBL23105463 | 0.70 | TLR8 (0.50) | PDE10ATLR7MAPT | |
| SCHEMBL10345238 | 0.70 | PDE10A (0.72) | PDE10ATLR7MAPTLMNA | |
| SCHEMBL9847092 | 0.69 | TLR8 (0.48) | PDE10ANPC1RAB9AGAARECQL | |
| SCHEMBL87693 | 0.68 | MAPT (0.50) | MAPTNPC1TP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3210984-B1 | HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF | SUNOVION PHARMACEUTICALS INC (US) | 2019-06-19 | — | — | EP | disclosed |