Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.54 |
| ▸ | TNKS | O95271 | 2/20 | 0.54 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.54 |
| ▸ | GSK3A | P49840 | 9/20 | 0.54 |
| ▸ | GSK3B | P49841 | 9/20 | 0.54 |
| ▸ | CCNB2 | O95067 | 9/20 | 0.54 |
| ▸ | CDK1 | P06493 | 9/20 | 0.54 |
| ▸ | CCNB1 | P14635 | 9/20 | 0.54 |
| ▸ | CCNB3 | Q8WWL7 | 9/20 | 0.54 |
| ▸ | CDK5 | Q00535 | 7/20 | 0.54 |
| ▸ | CDK5R1 | Q15078 | 7/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.46 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17236527 | 0.82 | TNKS (0.52) | PARP1TNKSTNKS2GSK3AGSK3B | |
| SCHEMBL4148211 | 0.82 | MGAM (0.57) | TNKSTNKS2GSK3AGSK3BCCNB2 | |
| SCHEMBL4157363 | 0.82 | MGAM (0.57) | TNKSTNKS2GSK3BAURKAKDM4E | |
| SCHEMBL17224938 | 0.82 | TNKS (0.49) | PARP1TNKSTNKS2 | |
| SCHEMBL1665479 | 0.81 | TNKS (0.51) | PARP1TNKSTNKS2 | |
| SCHEMBL4941364 | 0.81 | MAPK14 (0.52) | PARP1TNKSTNKS2GSK3AGSK3B | |
| SCHEMBL15972177 | 0.80 | PRMT5 (0.67) | — | |
| SCHEMBL4160756 | 0.80 | PARP1 (0.50) | PARP1GSK3AGSK3BCCNB2CDK1 | |
| SCHEMBL3927381 | 0.78 | TNKS (0.55) | PARP1TNKSTNKS2GSK3AGSK3B | |
| SCHEMBL15972383 | 0.78 | PRMT5 (0.67) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2804859-B1 | NOVEL FAP INHIBITORS | UNIV ANTWERPEN (BE) | 2019-06-12 | — | — | EP | disclosed |