Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR2B | P41595 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | PDE2A | O00408 | 3/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.35 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3101204 | 0.83 | HTR2A (0.44) | HTR2AHTR2BHTR2CPDE2ASLC6A4 | |
| SCHEMBL23841644 | 0.80 | DAO (0.44) | HTR2AHTR2BHTR2CPDE2ASLC6A4 | |
| SCHEMBL12844885 | 0.79 | PDE3B (0.45) | HTR2AHTR2BHTR2CPDE2ASLC6A4 | |
| SCHEMBL29453102 | 0.79 | IDO1 (0.53) | HTR2AHTR2BHTR2CPDE2ASLC6A4 | |
| SCHEMBL12304037 | 0.79 | IDO1 (0.53) | HTR2AHTR2BHTR2CPDE2ASLC6A4 | |
| SCHEMBL8225527 | 0.79 | IDO1 (0.53) | HTR2AHTR2BHTR2CPDE2ASLC6A4 | |
| SCHEMBL20651130 | 0.79 | HTR2A (0.42) | HTR2AHTR2BHTR2CPDE2ASLC6A4 | |
| SCHEMBL5907020 | 0.79 | HTR2A (0.42) | HTR2AHTR2BHTR2CPDE2ASLC6A4 | |
| SCHEMBL17069243 | 0.77 | SLC6A4 (0.52) | HTR2AHTR2BHTR2CPDE2ASLC6A4 | |
| SCHEMBL18682189 | 0.77 | PDE2A (0.53) | HTR2AHTR2BHTR2CPDE2ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019111225-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF NON‑ALCOHOLIC STEATOHEPATITIS | AVALIV THERAPEUTICS (US) | 2019-06-13 | — | — | WO | disclosed |