Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 1/20 | 0.72 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.56 |
| ▸ | CDK2 | P24941 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 5/20 | 0.56 |
| ▸ | FLT4 | P35916 | 4/20 | 0.56 |
| ▸ | FLT3 | P36888 | 4/20 | 0.56 |
| ▸ | KIT | P10721 | 2/20 | 0.56 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 4/20 | 0.53 |
| ▸ | GRK5 | P34947 | 1/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.53 |
| ▸ | JAK3 | P52333 | 1/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.52 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.52 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31726305 | 0.87 | PDGFRB (0.70) | ALKCCNE1CDK2KDRFLT4 | |
| SCHEMBL3273838 | 0.85 | ALK (0.79) | ALKKDRFLT4FLT3KIT | |
| SCHEMBL6520348 | 0.85 | ALK (0.58) | ALKCCNE1CDK2KDRFLT4 | |
| SCHEMBL6283603 | 0.85 | ALK (0.56) | ALKCCNE1CDK2KDRFLT4 | |
| SCHEMBL16486529 | 0.84 | ALK (0.78) | ALKKDRFLT4FLT3KIT | |
| SCHEMBL16490745 | 0.84 | ALK (0.78) | ALKKDRFLT4FLT3KIT | |
| SCHEMBL859966 | 0.84 | ALK (1.00) | ALKKDRFLT4FLT3KIT | |
| SCHEMBL3723130 | 0.84 | ALK (0.76) | ALKKDRFLT4FLT3KIT | |
| SCHEMBL2112712 | 0.84 | ALK (0.76) | ALKKDRFLT4FLT3KIT | |
| SCHEMBL18631714 | 0.84 | ALK (0.76) | ALKKDRFLT4FLT3KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8158656-B2 | 2-indolinone derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors | SHENZHEN CHIPSCREEN BIOSCIENCES LTD. (CN) | 2012-04-17 | — | — | US | disclosed |
| US-20090298886-A1 | 2-INDOLINONE DERIVATIVES AS MULTI-TARGET PROTEIN KINASE INHIBITORS AND HISTONE DEACETYLASE INHIBITORS | CHIPSCREEN BIOSCIENCES, LTD. (CN) | 2009-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090298886-A1 | 2-INDOLINONE DERIVATIVES AS MULTI-TARGET PROTEIN KINASE INHIBITORS AND HISTONE DEACETYLASE INHIBITORS | HDAC1, HDAC2, HDAC3 | ALK 3035/4885CCNE1 2512/4885CDK2 132/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.