Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 12/20 | 0.38 |
| ▸ | CCND1 | P24385 | 12/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 2/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | CCNE2 | O96020 | 4/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.34 |
| ▸ | CDK2 | P24941 | 4/20 | 0.34 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.34 |
| ▸ | CDK1 | P06493 | 2/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.34 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.34 |
| ▸ | CAMK2B | Q13554 | 4/20 | 0.33 |
| ▸ | CAMK2G | Q13555 | 4/20 | 0.33 |
| ▸ | CAMK2D | Q13557 | 4/20 | 0.33 |
| ▸ | CAMK2A | Q9UQM7 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21110952 | 0.91 | CDK4 (0.38) | CDK4CCND1CDK5CDK5R1GSK3A | |
| SCHEMBL21113548 | 0.91 | CDK4 (0.38) | CDK4CCND1CDK5CDK5R1GSK3A | |
| SCHEMBL21113544 | 0.91 | CDK4 (0.38) | CDK4CCND1CDK5CDK5R1GSK3A | |
| SCHEMBL21110712 | 0.91 | CDK4 (0.38) | CDK4CCND1CDK5CDK5R1GSK3A | |
| SCHEMBL19980383 | 0.85 | CDK4 (0.43) | CDK4CCND1CDK5CDK5R1GSK3A | |
| SCHEMBL16067513 | 0.77 | CDK4 (0.44) | CDK4CCND1TNKS2PTGESFEN1 | |
| SCHEMBL16067729 | 0.77 | CDK4 (0.44) | CDK4CCND1TNKS2PTGESFEN1 | |
| SCHEMBL16067505 | 0.76 | CDK4 (0.43) | CDK4CCND1TNKS2PTGESFEN1 | |
| SCHEMBL16067501 | 0.76 | CDK4 (0.43) | CDK4CCND1TNKS2PTGESFEN1 | |
| SCHEMBL16067518 | 0.76 | CDK4 (0.42) | CDK4CCND1TNKS2PTGESFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3512841-B1 | COMPOUNDS WITH SPIROBIFLUORENE-STRUCTURES | MERCK PATENT GMBH (DE) | 2023-04-26 | — | — | EP | disclosed |
| US-11447464-B2 | Compounds with spirobifluorene-structures | MERCK PATENT GMBH (DE) | 2022-09-20 | — | — | US | disclosed |
| US-20190194164-A1 | COMPOUNDS WITH SPIROBIFLUORENE-STRUCTURES | MERCK PATENT GMBH (DE) | 2019-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11447464-B2 | Compounds with spirobifluorene-structures | SLCO1B3, SLCO4C1, SLCO1B1 | CDK4 3036/4885CCND1 3424/4885TNKS2 2667/4885 |
| US-20190194164-A1 | COMPOUNDS WITH SPIROBIFLUORENE-STRUCTURES | SLCO1B3, SLCO4C1, SLCO1B1 | CDK4 3036/4885CCND1 3424/4885TNKS2 2667/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.