Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Abc-294640. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK2 known ✓ | Q9NRA0 | 4/20 | 1.00 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.72 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.65 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.52 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Abc-294640 SCHEMBL31060730 | 1.00 | SPHK2 (1.00) | SPHK2SPHK1CYP17A1CYP19A1ALDH1A1 | |
| Abc-294640 SCHEMBL20592375 | 1.00 | SPHK2 (1.00) | SPHK2SPHK1CYP17A1CYP19A1ALDH1A1 | |
| Abc-294640 SCHEMBL1548333 | 1.00 | SPHK2 (1.00) | SPHK2SPHK1CYP17A1CYP19A1ALDH1A1 | |
| Abc-294640 SCHEMBL29376156 | 0.99 | SPHK2 (0.98) | SPHK2SPHK1CYP17A1CYP19A1ALDH1A1 | |
| SCHEMBL1548364 | 0.89 | SPHK2 (0.81) | SPHK2SPHK1CYP17A1CYP19A1ALDH1A1 | |
| SCHEMBL1548422 | 0.89 | SPHK2 (0.80) | SPHK2SPHK1CYP17A1CYP19A1ALDH1A1 | |
| SCHEMBL24064926 | 0.89 | SPHK2 (0.80) | SPHK2SPHK1CYP17A1CYP19A1ALDH1A1 | |
| SCHEMBL1548107 | 0.89 | SPHK2 (0.80) | SPHK2SPHK1CYP17A1CYP19A1ALDH1A1 | |
| SCHEMBL1548319 | 0.87 | SPHK2 (0.77) | SPHK2SPHK1CYP17A1CYP19A1ALDH1A1 | |
| SCHEMBL1548110 | 0.86 | SPHK2 (0.76) | SPHK2SPHK1CYP17A1CYP19A1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10881643-B2 | Sphingosine pathway modulating compounds for the treatment of cancers | ENZO BIOCHEM, INC. (US) | 2021-01-05 | — | — | US | disclosed |
| US-20200230113-A1 | SPHINGOSINE PATHWAY MODULATING COMPOUNDS FOR THE TREATMENT OF CANCERS | ENZO BIOCHEM, INC. (US) | 2020-07-23 | — | — | US | disclosed |
| US-10646459-B2 | Sphingosine pathway modulating compounds for the treatment of cancers | ENZO BIOCHEM, INC. (US) | 2020-05-12 | — | — | US | disclosed |
| US-20190192451-A1 | SPHINGOSINE PATHWAY MODULATING COMPOUNDS FOR THE TREATMENT OF CANCERS | ENZO BIOCHEM, INC. (US) | 2019-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200230113-A1 | SPHINGOSINE PATHWAY MODULATING COMPOUNDS FOR THE TREATMENT OF CANCERS | S1PR1, SPHK1, S1PR4 | SPHK2 7/4885SPHK1 2/4885CYP17A1 2952/4885 |
| US-10881643-B2 | Sphingosine pathway modulating compounds for the treatment of cancers | S1PR1, SPHK1, S1PR4 | SPHK2 7/4885SPHK1 2/4885CYP17A1 2952/4885 |
| US-20190192451-A1 | SPHINGOSINE PATHWAY MODULATING COMPOUNDS FOR THE TREATMENT OF CANCERS | S1PR1, SPHK1, S1PR4 | SPHK2 7/4885SPHK1 2/4885CYP17A1 2952/4885 |
| US-10646459-B2 | Sphingosine pathway modulating compounds for the treatment of cancers | S1PR1, SPHK1, S1PR4 | SPHK2 7/4885SPHK1 2/4885CYP17A1 2952/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.