Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A | P35498 | 20/20 | 0.56 |
| ▸ | SCN8A | Q9UQD0 | 20/20 | 0.56 |
| ▸ | SCN5A | Q14524 | 4/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19631522 | 0.84 | SCN8A (0.57) | SCN1ASCN8ASCN5A | |
| SCHEMBL21117643 | 0.78 | SCN8A (0.44) | SCN1ASCN8ASCN5A | |
| SCHEMBL20237710 | 0.72 | SCN8A (1.00) | SCN1ASCN8ASCN5A | |
| SCHEMBL20237707 | 0.72 | SCN8A (1.00) | SCN1ASCN8ASCN5A | |
| SCHEMBL19613223 | 0.72 | SCN8A (1.00) | SCN1ASCN8ASCN5A | |
| SCHEMBL20256254 | 0.70 | SCN8A (0.78) | SCN1ASCN8ASCN5A | |
| SCHEMBL22646275 | 0.70 | SCN8A (0.77) | SCN1ASCN8A | |
| SCHEMBL19613430 | 0.69 | SCN8A (1.00) | SCN1ASCN8ASCN5A | |
| SCHEMBL19613019 | 0.69 | SCN8A (1.00) | SCN1ASCN8ASCN5A | |
| SCHEMBL19614292 | 0.69 | SCN8A (1.00) | SCN1ASCN8ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200354354-A1 | BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2020-11-12 | — | — | US | disclosed |
| US-10815229-B1 | Benzenesulfonamide compounds and their use as therapeutic agents | XENON PHARMACEUTICALS INC. (CA) | 2020-10-27 | — | — | US | disclosed |
| US-10662184-B2 | Benzenesulfonamide compounds and their use as therapeutic agents | XENON PHARMACEUTICALS INC. (CA) | 2020-05-26 | — | — | US | disclosed |
| US-20190194184-A1 | BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2019-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10815229-B1 | Benzenesulfonamide compounds and their use as therapeutic agents | SCN1A, SCN1B, SCN2B | SCN1A 1/4885SCN8A 14/4885SCN5A 11/4885 |
| US-10662184-B2 | Benzenesulfonamide compounds and their use as therapeutic agents | SCN1A, SCN1B, SCN2B | SCN1A 1/4885SCN8A 10/4885SCN5A 5/4885 |
| US-20200354354-A1 | BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | SCN1A, SCN1B, SCN2B | SCN1A 1/4885SCN8A 14/4885SCN5A 11/4885 |
| US-20190194184-A1 | BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | SCN1A, SCN1B, SCN2B | SCN1A 1/4885SCN8A 10/4885SCN5A 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.