⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17751390 | 0.82 | TSHR (0.65) | — | |
| SCHEMBL10239103 | 0.82 | TSHR (0.65) | — | |
| SCHEMBL9720211 | 0.82 | TSHR (0.65) | — | |
| SCHEMBL5610483 | 0.81 | — | — | |
| SCHEMBL8354344 | 0.77 | — | — | |
| SCHEMBL632271 | 0.77 | — | — | |
| SCHEMBL935573 | 0.77 | — | — | |
| SCHEMBL13244792 | 0.77 | — | — | |
| SCHEMBL2955268 | 0.75 | TSHR (0.43) | — | |
| SCHEMBL23249686 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116496404-A | Bispecific antibody targeting CD47 and PD-L1 and application thereof | 白先宏 | 2023-07-28 | — | — | CN | disclosed |
| US-20210123921-A1 | DIAGNOSTIC ASSAYS AND RELATED METHODS | C2Sense, Inc. (US) | 2021-04-29 | — | — | US | disclosed |
| EP-2003124-B1 | Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III | CHATHAM BIOTEC LTD (CA) | 2015-02-25 | — | — | EP | disclosed |
| EP-2121665-B1 | NITRODERIVATIVES AS ANGIOTENSIN II RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (US) | 2014-01-22 | — | — | EP | disclosed |
| US-8158655-B2 | Chymase inhibitors; to treat allergic, inflammatory and fibrotic diseases; 5-Fluoro-3-methyl-benzo[b]thiophene-2-sulfonic acid (4-bromo-2-trifluoromethyl-phenyl)-amide | HOFFMANN-LA ROCHE INC. (US) | 2012-04-17 | — | — | US | disclosed |
| EP-2168958-A1 | Isoindole-Imide Compounds, Compositions And Uses Thereof | CELGENE CORPORATION (US) | 2010-03-31 | — | — | EP | disclosed |
| US-20080167348-A1 | NOVEL SULFONAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-07-10 | — | — | US | disclosed |
| US-7375252-B2 | Compounds and method for the inhibition of the expression of VCAM-1 | ATHEROGENICS, INC. (US) | 2008-05-20 | — | — | US | disclosed |
| EP-0839040-B1 | USE OF CGMP-PHOSPHODIESTERASE INHIBITORS TO TREAT IMPOTENCE | ICOS CORP (US) | 2006-05-31 | — | — | EP | disclosed |
| US-20040220248-A1 | INDAZOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING PROTEIN KINASES, AND METHODS FOR THEIR USE | KANIA ROBERT STEVEN (US) | 2004-11-04 | — | — | US | disclosed |
| US-20030220495-A1 | Inhibitors of farnesyl protein transferase | ZENECA LIMITED AND ZENECA PHARMA S.A. | 2003-11-27 | — | — | US | disclosed |
| US-20020193446-A1 | Compounds and methods for the inhibition of the expression of VCAM-1 | CRABTREE ACQUISITION CO, LLC | 2002-12-19 | — | — | US | disclosed |
| US-6455662-B2 | CURING AGENT, CATALYST, ACCELERATOR OF A DERIVATIVE OF 1-(HYDROCARBYLOXYCARBONYL)IMIDAZOLE; LATENCY AT ROOM TEMPERATURE; HIGH ACTIVITY UPON HEATING; MOLDING MATERIALS; COATINGS; BONDING; LAMINATION; FOAMS; ELECTRICAL DEVICES | VANTICO INC. | 2002-09-24 | — | — | US | disclosed |
| US-20010051736-A1 | New taxoids produced by esterification at position 13 of taxoid ring; antitumor and antileukaemic properties | RHONE-POULENC RORER,S.A. | 2001-12-13 | — | — | US | disclosed |
| US-6268499-B1 | USEFUL AS RENIN INHIBITORS | HOFFMAN-LA ROCHE INC. | 2001-07-31 | — | — | US | disclosed |