SCHEMBL21134504

SCHEMBL21134504

CC(NC(=O)OC(C)(C)C)C(=O)NCC(=O)OCCOc1ccc(-c2c(C#N)c(SCc3csc(-c4ccc(Cl)cc4)n3)nc(N3CCCC3)c2C#N)cc1

nearest known ligand 0.52

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ADORA1 P30542 20/20 0.52
SLC6A3 Q01959 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13227751 0.95 ADORA1 (0.50) ADORA1SLC6A3
SCHEMBL20211455 0.94 ADORA1 (0.52) ADORA1SLC6A3
SCHEMBL20211453 0.94 ADORA1 (0.52) ADORA1SLC6A3
SCHEMBL3724537 0.94 ADORA1 (0.52) ADORA1SLC6A3
SCHEMBL20211459 0.94 ADORA1 (0.52) ADORA1SLC6A3
SCHEMBL20211443 0.94 ADORA1 (0.54) ADORA1SLC6A3
SCHEMBL3738904 0.94 ADORA1 (0.54) ADORA1SLC6A3
SCHEMBL3727107 0.92 ADORA1 (0.54) ADORA1SLC6A3
SCHEMBL3729431 0.92 ADORA1 (0.50) ADORA1SLC6A3
Hydrochloric Acid SCHEMBL3735467 0.91 ADORA1 (0.49) ADORA1SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3292133-B1 METHOD FOR THE PREPARATION OF 2-{4-[2-({[2-(4-CHLOROPHENYL) -1,3-THIAZOL-4-YL]METHYL}SULFANYL)-3,5-DICYAN-6- (PYRROLIDIN-1-YL)PYRIDIN-4-YL]PHENOXY}ETHYL-L-ALANYL-L-ALANINATE HYDROCHLORIDE Bayer Pharma AG (DE) 2019-06-26 EP disclosed