Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21136700 | 0.88 | KRAS (0.59) | KRAS | |
| SCHEMBL21137483 | 0.86 | KRAS (0.49) | KRAS | |
| SCHEMBL21136745 | 0.82 | ACKR3 (0.31) | ACKR3 | |
| SCHEMBL21136708 | 0.82 | KRAS (0.54) | KRAS | |
| SCHEMBL21099596 | 0.75 | KRAS (0.76) | KRAS | |
| SCHEMBL21136728 | 0.74 | KRAS (0.58) | KRAS | |
| SCHEMBL21099329 | 0.73 | KRAS (0.63) | KRAS | |
| SCHEMBL21099321 | 0.73 | KRAS (0.77) | KRAS | |
| SCHEMBL21137067 | 0.71 | KRAS (0.51) | KRAS | |
| SCHEMBL21136794 | 0.71 | KRAS (0.50) | KRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019110751-A1 | TETRACYCLIC COMPOUNDS AS INHIBITORS OF G12C MUTANT RAS PROTEIN, FOR USE AS ANTI-CANCER AGENTS | ASTRAZENECA AB (SE) | 2019-06-13 | — | — | WO | disclosed |