Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 20/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21050664 | 1.00 | KRAS (1.00) | KRAS | |
| SCHEMBL21050656 | 1.00 | KRAS (1.00) | KRAS | |
| SCHEMBL21050884 | 0.92 | KRAS (0.85) | KRAS | |
| SCHEMBL21050813 | 0.92 | KRAS (0.85) | KRAS | |
| SCHEMBL21050727 | 0.90 | KRAS (0.81) | KRAS | |
| SCHEMBL21099996 | 0.88 | KRAS (0.79) | KRAS | |
| SCHEMBL21099360 | 0.88 | KRAS (0.79) | KRAS | |
| SCHEMBL21099637 | 0.88 | KRAS (0.79) | KRAS | |
| SCHEMBL21050726 | 0.87 | KRAS (0.78) | KRAS | |
| SCHEMBL21050648 | 0.86 | KRAS (0.76) | KRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019110751-A1 | TETRACYCLIC COMPOUNDS AS INHIBITORS OF G12C MUTANT RAS PROTEIN, FOR USE AS ANTI-CANCER AGENTS | ASTRAZENECA AB (SE) | 2019-06-13 | — | — | WO | disclosed |