Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21136730 | 0.91 | KRAS (0.37) | KRAS | |
| SCHEMBL21136805 | 0.81 | HRH4 (0.40) | KRAS | |
| SCHEMBL21137333 | 0.80 | MAPK8 (0.38) | KRAS | |
| SCHEMBL21137567 | 0.75 | HRH4 (0.38) | KRAS | |
| SCHEMBL21136897 | 0.75 | SUV39H2 (0.42) | KRAS | |
| SCHEMBL21137341 | 0.72 | TP53 (0.35) | — | |
| SCHEMBL21137066 | 0.72 | KRAS (0.70) | KRAS | |
| SCHEMBL21137055 | 0.71 | KRAS (0.34) | KRAS | |
| SCHEMBL21137480 | 0.70 | MAP4K4 (0.40) | KRAS | |
| SCHEMBL21137331 | 0.69 | KRAS (0.62) | KRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019110751-A1 | TETRACYCLIC COMPOUNDS AS INHIBITORS OF G12C MUTANT RAS PROTEIN, FOR USE AS ANTI-CANCER AGENTS | ASTRAZENECA AB (SE) | 2019-06-13 | — | — | WO | disclosed |