Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | BRAF | P15056 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21137374 | 0.91 | HIF1A (0.33) | HIF1ACSF1RIRAK4 | |
| SCHEMBL21137371 | 0.87 | HIF1A (0.34) | HIF1AIRAK4 | |
| SCHEMBL21136494 | 0.86 | HIF1A (0.33) | HIF1AIRAK4BRAF | |
| SCHEMBL19644597 | 0.81 | HIF1A (0.37) | HIF1ACSF1R | |
| SCHEMBL21137373 | 0.81 | HIF1A (0.34) | HIF1A | |
| SCHEMBL21137368 | 0.80 | HIF1A (0.33) | HIF1AIRAK4 | |
| SCHEMBL19644583 | 0.79 | HIF1A (0.39) | HIF1AIRAK4 | |
| SCHEMBL21137365 | 0.79 | HIF1A (0.33) | HIF1AIRAK4BRAF | |
| SCHEMBL17453461 | 0.79 | HIF1A (0.35) | HIF1A | |
| SCHEMBL17453473 | 0.75 | HIF1A (0.36) | HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190194223-A1 | THIENO[3,2-d]PYRIMIDINE, FURO[3,2-d]PYRIMIDINE, AND PYRROLO[3,2-D]PYRIMIDINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS | GILEAD SCIENCES, INC. | 2019-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190194223-A1 | THIENO[3,2-d]PYRIMIDINE, FURO[3,2-d]PYRIMIDINE, AND PYRROLO[3,2-D]PYRIMIDINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS | DPYD, TYMS, TYMP | HIF1A 2400/4885CSF1R 2449/4885IRAK4 2655/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.