Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 17/20 | 0.51 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.37 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21099346 | 0.80 | KRAS (0.55) | KRAS | |
| SCHEMBL29765795 | 0.79 | KRAS (0.54) | KRASHAVCR2 | |
| SCHEMBL17030835 | 0.79 | KRAS (0.54) | KRASHAVCR2 | |
| SCHEMBL21099360 | 0.75 | KRAS (0.79) | KRAS | |
| SCHEMBL21099996 | 0.75 | KRAS (0.79) | KRAS | |
| SCHEMBL16647033 | 0.73 | KRAS (0.48) | KRASSUV39H2HAVCR2 | |
| SCHEMBL19412040 | 0.72 | KRAS (0.73) | KRAS | |
| SCHEMBL29765698 | 0.72 | KRAS (0.69) | KRAS | |
| SCHEMBL16646907 | 0.72 | KRAS (0.69) | KRAS | |
| SCHEMBL16647073 | 0.71 | KRAS (0.68) | KRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019110751-A1 | TETRACYCLIC COMPOUNDS AS INHIBITORS OF G12C MUTANT RAS PROTEIN, FOR USE AS ANTI-CANCER AGENTS | ASTRAZENECA AB (SE) | 2019-06-13 | — | — | WO | disclosed |