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Sugi Predict / Compounds / SCHEMBL21139704

SCHEMBL21139704

SCHEMBL21139704

O=C(NCC(O)CN1CCc2ccccc2C1)c1cncc(OC2CCN(CC(F)(F)F)CC2)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ PRMT5 O14744 20/20 1.00
▸ WDR77 Q9BQA1 19/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16217548 1.00 PRMT5 (1.00) PRMT5WDR77
SCHEMBL21139764 0.90 PRMT5 (0.81) PRMT5WDR77
SCHEMBL16217546 0.90 PRMT5 (0.81) PRMT5WDR77
SCHEMBL16217454 0.89 PRMT5 (0.80) PRMT5WDR77
SCHEMBL16220708 0.88 PRMT5 (0.78) PRMT5WDR77
SCHEMBL21139776 0.88 PRMT5 (0.78) PRMT5WDR77
SCHEMBL16217538 0.87 PRMT5 (0.78) PRMT5WDR77
SCHEMBL21140473 0.87 PRMT5 (0.78) PRMT5WDR77
SCHEMBL21137848 0.87 PRMT5 (0.80) PRMT5WDR77
SCHEMBL16217502 0.87 PRMT5 (0.80) PRMT5WDR77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4219465-A2 PRMT5 INHIBITORS AND USES THEREOF Epizyme Inc (US) 2023-08-02 — — EP disclosed
EP-3498701-B1 PRMT5 INHIBITORS AND USES THEREOF EPIZYME INC (US) 2023-02-22 — — EP disclosed
EP-3498701-A1 PRMT5 INHIBITORS AND USES THEREOF Epizyme Inc (US) 2019-06-19 — — EP disclosed