Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HRH1 | P35367 | 1/20 | 0.52 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5207756 | 0.85 | HRH3 (0.65) | HRH3HRH1CXCR4MEN1KMT2A | |
| SCHEMBL13450155 | 0.85 | SMN1; SMN2 (0.71) | HRH3GAASMN1; SMN2MAOAMAOB | |
| SCHEMBL5202557 | 0.82 | HRH3 (0.67) | HRH3SMN1; SMN2HRH1 | |
| SCHEMBL15830271 | 0.82 | GAA (0.54) | HRH3GAASMN1; SMN2MEN1KMT2A | |
| SCHEMBL2365784 | 0.82 | HRH1 (0.66) | HRH3HRH1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL31587835 | 0.82 | GAA (0.54) | HRH3GAASMN1; SMN2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL31587801 | 0.81 | HRH1 (0.63) | HRH3HRH1MEN1KMT2A | |
| SCHEMBL1004964 | 0.80 | HRH3 (0.49) | HRH3SMN1; SMN2HRH1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL23410284 | 0.79 | HRH1 (0.61) | HRH3HRH1MEN1KMT2A | |
| SCHEMBL30775254 | 0.77 | HRH3 (0.62) | HRH3HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219465-A2 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme Inc (US) | 2023-08-02 | — | — | EP | disclosed |
| EP-3498701-A1 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme Inc (US) | 2019-06-19 | — | — | EP | disclosed |