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SCHEMBL21139922

SCHEMBL21139922

CN1CCN(Cc2cccc(C(=O)NC[C@H](O)CN3CCc4ccccc4C3)c2)CC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ PRMT5 O14744 20/20 1.00
▸ WDR77 Q9BQA1 13/20 0.83

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15825497 1.00 PRMT5 (1.00) PRMT5WDR77
SCHEMBL32617524 1.00 PRMT5 (1.00) PRMT5WDR77
SCHEMBL16217446 0.94 PRMT5 (0.88) PRMT5WDR77
SCHEMBL16217457 0.93 PRMT5 (0.86) PRMT5WDR77
SCHEMBL16217456 0.92 PRMT5 (0.85) PRMT5WDR77
SCHEMBL16217574 0.92 PRMT5 (0.85) PRMT5WDR77
SCHEMBL16220857 0.92 PRMT5 (0.85) PRMT5WDR77
SCHEMBL16217483 0.92 PRMT5 (0.85) PRMT5WDR77
SCHEMBL16217485 0.91 PRMT5 (0.84) PRMT5WDR77
SCHEMBL25059487 0.91 PRMT5 (0.83) PRMT5WDR77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4219465-A2 PRMT5 INHIBITORS AND USES THEREOF Epizyme Inc (US) 2023-08-02 — — EP disclosed
EP-3498701-A1 PRMT5 INHIBITORS AND USES THEREOF Epizyme Inc (US) 2019-06-19 — — EP disclosed