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SCHEMBL21140520

SCHEMBL21140520

CNCCOc1ccc2cc(C(=O)NCC(O)CN3CCc4ccccc4C3)ccc2c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ PRMT5 O14744 20/20 1.00
▸ WDR77 Q9BQA1 19/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17308342 1.00 PRMT5 (1.00) PRMT5WDR77
SCHEMBL21140205 0.92 PRMT5 (0.85) PRMT5WDR77
SCHEMBL17308505 0.92 PRMT5 (0.85) PRMT5WDR77
SCHEMBL21140203 0.92 PRMT5 (0.84) PRMT5WDR77
SCHEMBL17308391 0.92 PRMT5 (0.84) PRMT5WDR77
SCHEMBL15835824 0.91 PRMT5 (1.00) PRMT5WDR77
SCHEMBL21139979 0.90 PRMT5 (0.81) PRMT5WDR77
SCHEMBL17308478 0.90 PRMT5 (0.81) PRMT5WDR77
SCHEMBL17306890 0.90 PRMT5 (1.00) PRMT5WDR77
SCHEMBL21139980 0.90 PRMT5 (1.00) PRMT5WDR77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4219465-A2 PRMT5 INHIBITORS AND USES THEREOF Epizyme Inc (US) 2023-08-02 — — EP disclosed
EP-3498701-B1 PRMT5 INHIBITORS AND USES THEREOF EPIZYME INC (US) 2023-02-22 — — EP disclosed
EP-3498701-A1 PRMT5 INHIBITORS AND USES THEREOF Epizyme Inc (US) 2019-06-19 — — EP disclosed