Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 2/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.34 |
| ▸ | METTL3 | Q86U44 | 2/20 | 0.33 |
| ▸ | NAPEPLD | Q6IQ20 | 3/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.31 |
| ▸ | KDM5A | P29375 | 2/20 | 0.31 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.31 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.31 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | F11 | P03951 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | KDM4A | O75164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21143958 | 0.94 | IDH1 (0.35) | IDH1P2RX7METTL3NAPEPLDCCNT1 | |
| SCHEMBL21144021 | 0.92 | CCNA2 (0.36) | IDH1CCNA2CDK2CDK5CDK5R1 | |
| SCHEMBL21143975 | 0.90 | IDH1 (0.34) | IDH1CCNA2CDK2CDK5CDK5R1 | |
| SCHEMBL31127100 | 0.90 | IDH1 (0.34) | IDH1CCNA2CDK2CDK5CDK5R1 | |
| SCHEMBL21166293 | 0.90 | IDH1 (0.34) | IDH1CCNA2CDK2CDK5CDK5R1 | |
| SCHEMBL21143628 | 0.85 | CCNA2 (0.39) | IDH1CCNA2CDK2CDK5CDK5R1 | |
| SCHEMBL19686343 | 0.85 | IDH1 (0.35) | IDH1CCNA2CDK2CDK5CDK5R1 | |
| SCHEMBL21143761 | 0.84 | IDH1 (0.42) | IDH1CCNA2CDK2CDK5CDK5R1 | |
| SCHEMBL19686925 | 0.84 | IDH1 (0.34) | IDH1P2RX7METTL3NAPEPLDF2 | |
| SCHEMBL19686404 | 0.84 | IDH1 (0.34) | IDH1P2RX7METTL3NAPEPLDF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10774064-B2 | Potassium channel modulators | CADENT THERAPEUTICS, INC. (US) | 2020-09-15 | — | — | US | disclosed |
| US-20190218200-A1 | POTASSIUM CHANNEL MODULATORS | NOVARTIS AG (CH) | 2019-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10774064-B2 | Potassium channel modulators | KCNJ11, KCNJ2, KCNJ1 | IDH1 3017/4885CCNA2 4797/4885CDK2 4098/4885 |
| US-20190218200-A1 | POTASSIUM CHANNEL MODULATORS | KCNJ11, KCNJ2, KCNJ1 | IDH1 3017/4885CCNA2 4797/4885CDK2 4098/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.