Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 15/20 | 0.42 |
| ▸ | IDH2 | P48735 | 3/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | CD38 | P28907 | 1/20 | 0.32 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.32 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21143835 | 0.85 | IDH1 (0.44) | IDH1IDH2GSK3BDYRK1ACD38 | |
| SCHEMBL31127106 | 0.85 | IDH1 (0.44) | IDH1IDH2GSK3BDYRK1ACD38 | |
| SCHEMBL21144008 | 0.84 | IDH1 (0.43) | IDH1IDH2CD38 | |
| SCHEMBL19686966 | 0.84 | IDH1 (0.45) | IDH1IDH2 | |
| SCHEMBL19686734 | 0.84 | IDH1 (0.50) | IDH1IDH2 | |
| SCHEMBL31127138 | 0.84 | IDH1 (0.50) | IDH1IDH2 | |
| SCHEMBL21144351 | 0.83 | IDH1 (0.47) | IDH1IDH2 | |
| SCHEMBL19686292 | 0.83 | IDH1 (0.47) | IDH1IDH2 | |
| SCHEMBL31127241 | 0.83 | IDH1 (0.47) | IDH1IDH2 | |
| SCHEMBL19686392 | 0.82 | IDH1 (0.43) | IDH1IDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190218200-A1 | POTASSIUM CHANNEL MODULATORS | NOVARTIS AG (CH) | 2019-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190218200-A1 | POTASSIUM CHANNEL MODULATORS | KCNJ11, KCNJ2, KCNJ1 | IDH1 3017/4885IDH2 2447/4885GSK3B 2806/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.