Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.47 |
| ▸ | RORC | P51449 | 2/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 12/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.40 |
| ▸ | INSR | P06213 | 2/20 | 0.39 |
| ▸ | LCK | P06239 | 2/20 | 0.39 |
| ▸ | LTK | P29376 | 2/20 | 0.39 |
| ▸ | AXL | P30530 | 2/20 | 0.39 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.39 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.39 |
| ▸ | MERTK | Q12866 | 2/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21147684 | 0.99 | EGFR (0.48) | EGFRRORCALKOPRM1OPRD1 | |
| SCHEMBL17586605 | 0.90 | EGFR (0.50) | EGFRRORCALKOPRM1OPRD1 | |
| SCHEMBL17586604 | 0.89 | EGFR (0.51) | EGFRRORCALKOPRM1OPRD1 | |
| SCHEMBL17586627 | 0.88 | EGFR (0.49) | EGFRRORCALKOPRM1OPRD1 | |
| SCHEMBL30659112 | 0.87 | ALK (0.47) | EGFRALKOPRM1OPRD1OPRK1 | |
| SCHEMBL17582756 | 0.87 | ALK (0.47) | EGFRALKOPRM1OPRD1OPRK1 | |
| SCHEMBL30659155 | 0.86 | ALK (0.48) | EGFRALKOPRM1OPRD1OPRK1 | |
| SCHEMBL17582732 | 0.86 | ALK (0.48) | EGFRALKOPRM1OPRD1OPRK1 | |
| SCHEMBL17586655 | 0.85 | EGFR (0.52) | EGFRRORCALKOPRM1OPRD1 | |
| SCHEMBL17583005 | 0.84 | ALK (0.48) | EGFRALKOPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3191457-B1 | BENZOIMIDAZOL-1,2-YL AMIDES AS Kv7 CHANNEL ACTIVATORS | KNOPP BIOSCIENCES LLC (US) | 2019-07-10 | — | — | EP | disclosed |