Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | ANPEP | P15144 | 1/20 | 0.36 |
| ▸ | F13A1 | P00488 | 1/20 | 0.35 |
| ▸ | TGM2 | P21980 | 1/20 | 0.35 |
| ▸ | TGM1 | P22735 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8274294 | 0.86 | NR1H2 (0.41) | CHRM2CHRM1CHRM3NR1H2MMP2 | |
| SCHEMBL20713877 | 0.86 | CHRM2 (0.47) | CHRM2CHRM1CHRM3NR1H2F13A1 | |
| SCHEMBL10198283 | 0.86 | NR1H2 (0.41) | CHRM2CHRM1CHRM3NR1H2MMP2 | |
| SCHEMBL19865492 | 0.86 | CHRM2 (0.47) | CHRM2CHRM1CHRM3NR1H2F13A1 | |
| SCHEMBL10145613 | 0.82 | NR1H2 (0.43) | CHRM2CHRM1CHRM3NR1H2F13A1 | |
| SCHEMBL609152 | 0.82 | NR1H2 (0.43) | CHRM2CHRM1CHRM3NR1H2F13A1 | |
| SCHEMBL607607 | 0.82 | NR1H2 (0.43) | CHRM2CHRM1CHRM3NR1H2F13A1 | |
| SCHEMBL1267911 | 0.81 | NR1H2 (0.38) | CHRM2CHRM1CHRM3NR1H2MMP2 | |
| SCHEMBL3964957 | 0.81 | NR1H2 (0.38) | CHRM2CHRM1CHRM3NR1H2MMP2 | |
| SCHEMBL1268168 | 0.81 | NR1H2 (0.38) | CHRM2CHRM1CHRM3NR1H2MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3508482-B1 | INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR AND USE THEREOF | NANJING TRANSTHERA BIOSCIENCES CO LTD (CN) | 2020-12-16 | — | — | EP | disclosed |
| EP-3508482-A1 | INHIBITORS OF FIBROBLAST GROWTH FACTOR RECEPTOR AND USE THEREOF | Nanjing Transthera Biosciences Co. Ltd. (CN) | 2019-07-10 | — | — | EP | disclosed |