Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 4/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | OGFRL1 | Q5TC84 | 2/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | PRKCH | P24723 | 1/20 | 0.38 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | CACNG2 | Q9Y698 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.34 |
| ▸ | HTR3B | O95264 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.34 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2115435 | 1.00 | GRIA1 (0.38) | GRIA1AOC3OPRK1OPRM1OGFRL1 | |
| SCHEMBL2115290 | 0.84 | PRKCH (0.37) | GRIA1AOC3OPRK1OPRM1OGFRL1 | |
| SCHEMBL2115287 | 0.84 | PRKCH (0.37) | GRIA1AOC3OPRK1OPRM1OGFRL1 | |
| SCHEMBL14480681 | 0.81 | SOS1 (0.37) | GRIA1OPRK1OPRM1OGFRL1OPRD1 | |
| SCHEMBL14480684 | 0.81 | SOS1 (0.37) | GRIA1OPRK1OPRM1OGFRL1OPRD1 | |
| SCHEMBL2113571 | 0.77 | DPP4 (0.36) | GRIA1AOC3OPRK1PRKCHPRKCE | |
| SCHEMBL2113563 | 0.77 | DPP4 (0.36) | GRIA1AOC3OPRK1PRKCHPRKCE | |
| SCHEMBL716475 | 0.76 | PIK3CD (0.40) | OPRK1OPRM1OGFRL1OPRD1PRKCH | |
| SCHEMBL717871 | 0.76 | PRKCH (0.38) | GRIA1OPRK1OPRM1OGFRL1OPRD1 | |
| SCHEMBL717872 | 0.76 | PRKCH (0.38) | GRIA1OPRK1OPRM1OGFRL1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120095005-A1 | Fused Bicyclic Pyrazole Derivatives As Kinase Inhibitors | UCB PHARMA S.A. (BE) | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095005-A1 | Fused Bicyclic Pyrazole Derivatives As Kinase Inhibitors | PI4KA, PDPK1, PIK3CA | GRIA1 647/4885AOC3 1957/4885OPRK1 305/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.