Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 1/20 | 0.47 |
| ▸ | CRHR1 | P34998 | 6/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.31 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9104427 | 0.82 | AHR (0.49) | AHR | |
| SCHEMBL9107317 | 0.80 | AHR (0.53) | AHRSLC6A2 | |
| SCHEMBL9108306 | 0.78 | AHR (0.46) | AHRMAPT | |
| SCHEMBL20619998 | 0.73 | AHR (0.53) | AHR | |
| SCHEMBL20472465 | 0.72 | AHR (0.46) | AHR | |
| SCHEMBL9105474 | 0.72 | AHR (0.46) | AHR | |
| SCHEMBL616699 | 0.71 | AHR (0.57) | AHRMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL31096177 | 0.71 | AHR (0.57) | AHRMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL9104806 | 0.70 | AHR (0.61) | AHRJAK2JAK3 | |
| SCHEMBL20472412 | 0.68 | AHR (0.41) | AHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019134978-A1 | 1, 3, 4, 5-TETRAHYDRO-2H-PYRIDO[4,3-B]INDOLE DERIVATIVES FOR THE TREATMENT, ALLEVIATION OR PREVENTION OF DISORDERS ASSOCIATED WITH TAU AGGREGATES LIKE ALZHEIMER'S DISEASE | AC IMMUNE SA (CH) | 2019-07-11 | — | — | WO | disclosed |