Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12435367 | 0.79 | USP2 (0.42) | USP2SMN1; SMN2MAPK1HDAC1NR1H2 | |
| SCHEMBL13801225 | 0.78 | USP2 (0.50) | USP2SMN1; SMN2MAPK1HDAC1NR1H2 | |
| SCHEMBL19080544 | 0.76 | NR1H2 (0.47) | USP2SMN1; SMN2MAPK1HDAC1NR1H2 | |
| SCHEMBL24535479 | 0.70 | USP2 (0.36) | USP2SMN1; SMN2MAPK1HDAC1NR1H2 | |
| SCHEMBL16224510 | 0.70 | USP2 (0.43) | USP2SMN1; SMN2MAPK1HDAC1NR1H2 | |
| SCHEMBL12435353 | 0.70 | NR1H2 (0.44) | USP2SMN1; SMN2MAPK1HDAC1NR1H2 | |
| SCHEMBL18571170 | 0.70 | USP2 (0.40) | USP2SMN1; SMN2MAPK1HDAC1NR1H2 | |
| SCHEMBL1488405 | 0.70 | USP2 (0.46) | USP2SMN1; SMN2MAPK1HDAC1NR1H2 | |
| SCHEMBL14719429 | 0.69 | USP2 (0.42) | USP2SMN1; SMN2MAPK1HDAC1NR1H2 | |
| SCHEMBL13801202 | 0.69 | USP2 (0.39) | USP2SMN1; SMN2MAPK1HDAC1NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019134978-A1 | 1, 3, 4, 5-TETRAHYDRO-2H-PYRIDO[4,3-B]INDOLE DERIVATIVES FOR THE TREATMENT, ALLEVIATION OR PREVENTION OF DISORDERS ASSOCIATED WITH TAU AGGREGATES LIKE ALZHEIMER'S DISEASE | AC IMMUNE SA (CH) | 2019-07-11 | — | — | WO | disclosed |