Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30455049 | 0.86 | PTPN11 (0.43) | PTPN11KCNH2 | |
| SCHEMBL19785261 | 0.86 | PTPN11 (0.43) | PTPN11KCNH2 | |
| SCHEMBL19785424 | 0.82 | PTPN11 (0.53) | PTPN11KCNH2 | |
| SCHEMBL30295972 | 0.81 | PTPN11 (0.49) | PTPN11KCNH2 | |
| SCHEMBL19785263 | 0.81 | PTPN11 (0.49) | PTPN11KCNH2 | |
| SCHEMBL19785262 | 0.80 | PTPN11 (0.49) | PTPN11KCNH2 | |
| SCHEMBL19785345 | 0.80 | PTPN11 (0.51) | PTPN11KCNH2 | |
| SCHEMBL30455607 | 0.80 | PTPN11 (0.51) | PTPN11KCNH2 | |
| SCHEMBL21115194 | 0.79 | PTPN11 (0.47) | PTPN11KCNH2 | |
| SCHEMBL30295748 | 0.78 | PTPN11 (0.52) | PTPN11KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190210977-A1 | 2,5-DISUBSTITUTED 3-METHYL PYRAZINES AND 2,5,6-TRISUBSTITUTED 3-METHYL PYRAZINES AS ALLOSTERIC SHP2 INHIBITORS | WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT | 2019-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190210977-A1 | 2,5-DISUBSTITUTED 3-METHYL PYRAZINES AND 2,5,6-TRISUBSTITUTED 3-METHYL PYRAZINES AS ALLOSTERIC SHP2 INHIBITORS | PTPN5, PTPN2, PTPN22 | PTPN11 12/4885KCNH2 3436/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.