Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 20/20 | 0.67 |
| ▸ | PARP2 | Q9UGN5 | 11/20 | 0.67 |
| ▸ | PARP3 | Q9Y6F1 | 11/20 | 0.67 |
| ▸ | TNKS | O95271 | 1/20 | 0.67 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.67 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.67 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.67 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.67 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.67 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.67 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.67 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.67 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.67 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.67 |
| ▸ | PARP12 | Q9H0J9 | 1/20 | 0.67 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.67 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.67 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.67 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26159121 | 1.00 | PARP1 (0.67) | PARP1PARP2PARP3TNKSCHRM2 | |
| SCHEMBL24302313 | 0.91 | PARP1 (0.62) | PARP1PARP2PARP3TNKSCHRM2 | |
| SCHEMBL26196985 | 0.90 | PARP1 (0.54) | PARP1PARP2PARP3TNKSCHRM2 | |
| SCHEMBL21036416 | 0.88 | PARP1 (0.69) | PARP1PARP2PARP3TNKSCHRM2 | |
| SCHEMBL24301101 | 0.88 | PARP1 (0.69) | PARP1PARP2PARP3TNKSCHRM2 | |
| SCHEMBL24235609 | 0.88 | PARP1 (0.69) | PARP1PARP2PARP3TNKSCHRM2 | |
| SCHEMBL24950168 | 0.86 | PARP1 (0.67) | PARP1PARP2PARP3TNKSCHRM2 | |
| SCHEMBL25938739 | 0.86 | PARP1 (0.67) | PARP1PARP2PARP3TNKSCHRM2 | |
| SCHEMBL23854758 | 0.86 | PARP1 (0.61) | PARP1PARP2PARP3TNKSCHRM2 | |
| SCHEMBL1421856 | 0.86 | PARP1 (0.61) | PARP1PARP2PARP3TNKSCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230270874-A1 | ANTIBODY DRUG CONJUGATE LOADED WITH BINARY TOXINS AND ITS APPLICATION | MABPLEX INTERNATIONAL CO., LTD. (CN) | 2023-08-31 | — | — | US | disclosed |
| US-20230158152-A1 | PROTEOLYSIS REGULATOR AND METHOD FOR USING SAME | MEDSHINE DISCOVERY INC. (CN) | 2023-05-25 | — | — | US | disclosed |
| US-20230158152-A1 | PROTEOLYSIS REGULATOR AND METHOD FOR USING SAME | MEDSHINE DISCOVERY INC. (CN) | 2023-05-25 | — | — | US | disclosed |
| US-20220117982-A1 | TARGET PROTEIN DEGRADATION COMPOUNDS, THEIR ANTI-TUMOR USE, THEIR INTERMEDIATES AND USE OF INTERMEDIATES | SHANGHAITECH UNIVERSITY (CN) | 2022-04-21 | — | — | US | disclosed |
| US-20210299137-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR TREATMENT OF DISEASES INVOLVING ACIDIC OR HYPOXIC DISEASED TISSUES | CYBREXA 1, INC. | 2021-09-30 | — | — | US | disclosed |
| US-10933069-B2 | Compounds, compositions, and methods for treatment of diseases involving acidic or hypoxic diseased tissues | CYBREXA 1, INC. (US) | 2021-03-02 | — | — | US | disclosed |
| US-20190209580-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR TREATMENT OF DISEASES INVOLVING ACIDIC OR HYPOXIC DISEASED TISSUES | CYBREXA 1, INC. | 2019-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230158152-A1 | PROTEOLYSIS REGULATOR AND METHOD FOR USING SAME | PSMA6, PSMC1, PSMA1 | PARP1 1313/4885PARP2 1875/4885PARP3 849/4885 |
| US-20230270874-A1 | ANTIBODY DRUG CONJUGATE LOADED WITH BINARY TOXINS AND ITS APPLICATION | MMAB, TNFSF10, CD47 | PARP1 1463/4885PARP2 1105/4885PARP3 664/4885 |
| US-20210299137-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR TREATMENT OF DISEASES INVOLVING ACIDIC OR HYPOXIC DISEASED TISSUES | HIF1A, HIF1AN, VHL | PARP1 1881/4885PARP2 1429/4885PARP3 2265/4885 |
| US-20220117982-A1 | TARGET PROTEIN DEGRADATION COMPOUNDS, THEIR ANTI-TUMOR USE, THEIR INTERMEDIATES AND USE OF INTERMEDIATES | UFM1, SUMO1, SUMO2 | PARP1 1787/4885PARP2 1818/4885PARP3 1005/4885 |
| US-10933069-B2 | Compounds, compositions, and methods for treatment of diseases involving acidic or hypoxic diseased tissues | HIF1A, HIF1AN, VHL | PARP1 1881/4885PARP2 1429/4885PARP3 2265/4885 |
| US-20190209580-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR TREATMENT OF DISEASES INVOLVING ACIDIC OR HYPOXIC DISEASED TISSUES | HIF1A, HIF1AN, VHL | PARP1 1881/4885PARP2 1429/4885PARP3 2265/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.