Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL212445 | 1.00 | ABL1 (0.31) | ABL1EGFRCTSK | |
| SCHEMBL210285 | 0.98 | ABL1 (0.32) | ABL1EGFRCTSK | |
| SCHEMBL210281 | 0.98 | ABL1 (0.32) | ABL1EGFRCTSK | |
| SCHEMBL210741 | 0.92 | — | — | |
| SCHEMBL211896 | 0.92 | — | — | |
| SCHEMBL210105 | 0.90 | ABL1 (0.30) | ABL1 | |
| SCHEMBL211245 | 0.90 | ABL1 (0.30) | ABL1 | |
| SCHEMBL2726121 | 0.89 | EGFR (0.32) | ABL1EGFRCTSK | |
| SCHEMBL210437 | 0.89 | ABL1 (0.33) | ABL1 | |
| SCHEMBL9608011 | 0.89 | EGFR (0.32) | ABL1EGFRCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088793-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2012-01-03 | — | — | US | claimed |
| US-8088793-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2012-01-03 | — | — | US | disclosed |