Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 3/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | QDPR | P09417 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18113590 | 0.80 | TRPV1 (0.47) | KMT2AMEN1SMN1; SMN2CNR1JAK1 | |
| SCHEMBL18113482 | 0.77 | MEN1 (0.43) | KMT2AMEN1CNR1GAAJAK1 | |
| SCHEMBL186753 | 0.77 | MEN1 (0.52) | KMT2AMEN1SMN1; SMN2CNR1JAK1 | |
| SCHEMBL27886023 | 0.76 | MEN1 (0.71) | KMT2AMEN1SMN1; SMN2L3MBTL1CNR1 | |
| SCHEMBL18121828 | 0.76 | NOTUM (0.49) | KMT2AMEN1CNR1NOTUMJAK1 | |
| SCHEMBL18113564 | 0.76 | KDM4E (0.51) | KMT2AMEN1HSD17B10CNR1JAK1 | |
| SCHEMBL1198534 | 0.75 | MEN1 (0.51) | KMT2AMEN1SMN1; SMN2CNR1JAK1 | |
| SCHEMBL18113493 | 0.73 | MEN1 (0.43) | KMT2AMEN1CNR1JAK1QDPR | |
| SCHEMBL18113611 | 0.73 | MEN1 (0.43) | KMT2AMEN1SMN1; SMN2CNR1NOTUM | |
| SCHEMBL20414631 | 0.72 | MEN1 (0.45) | KMT2AMEN1SMN1; SMN2CNR1JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190201380-A1 | SPIROCYCLIC COMPOUNDS | KALYRA PHARMACEUTICALS, INC. | 2019-07-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190201380-A1 | SPIROCYCLIC COMPOUNDS | PKD1, AR, PKD2 | KMT2A 3524/4885MEN1 840/4885SMN1; SMN2 3334/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.