Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 10/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | FNTA | P49354 | 1/20 | 0.45 |
| ▸ | FNTB | P49356 | 1/20 | 0.45 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL875321 | 0.88 | AR (0.57) | ARKDM4EHTTSMN1; SMN2CYP1A2 | |
| SCHEMBL883467 | 0.88 | MAOB (0.46) | ARCYP1A2CYP2C9CYP2C19RECQL | |
| SCHEMBL875066 | 0.88 | AR (0.44) | ARKDM4EHTTSMN1; SMN2CYP1A2 | |
| SCHEMBL875988 | 0.88 | SCN9A (0.44) | ARKDM4EHTTSMN1; SMN2CYP1A2 | |
| SCHEMBL883471 | 0.88 | SCN9A (0.44) | ARKDM4EHTTSMN1; SMN2CYP1A2 | |
| SCHEMBL29769048 | 0.88 | AR (0.57) | ARKDM4EHTTSMN1; SMN2CYP1A2 | |
| SCHEMBL875333 | 0.86 | AR (0.45) | ARKDM4EHTTSMN1; SMN2CYP1A2 | |
| SCHEMBL875684 | 0.85 | SCN9A (0.47) | ARKDM4EHTTSMN1; SMN2CYP1A2 | |
| SCHEMBL9109349 | 0.85 | CYP1A2 (0.44) | ARKDM4EHTTSMN1; SMN2CYP1A2 | |
| SCHEMBL883763 | 0.85 | CYP1A2 (0.44) | ARKDM4EHTTSMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3172211-B1 | TRICYCLIC IMIDAZO-PYRIMIDINONE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY LP-PLA2 | GLAXOSMITHKLINE IP DEV LTD (GB) | 2019-07-03 | — | — | EP | disclosed |