Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SKP2 | Q13309 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 3/20 | 0.43 |
| ▸ | CYP4A11 | Q02928 | 4/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.42 |
| ▸ | BCHE | P06276 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ATP4A | P20648 | 1/20 | 0.39 |
| ▸ | ATP4B | P51164 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8240201 | 0.95 | BCHE (0.47) | SKP2BACE1SLC6A2SLC6A4CA2 | |
| SCHEMBL23092976 | 0.85 | SKP2 (0.65) | SKP2BACE1CA2ALDH1A1POLB | |
| SCHEMBL2154431 | 0.85 | BACE1 (0.50) | SKP2BACE1ALDH1A1POLBMAPT | |
| SCHEMBL15175048 | 0.84 | SKP2 (0.58) | SKP2SLC6A2SLC6A4CA2ALDH1A1 | |
| SCHEMBL5830998 | 0.82 | SKP2 (0.56) | SKP2SLC6A2SLC6A4CA2ALDH1A1 | |
| SCHEMBL2561468 | 0.82 | SKP2 (0.56) | SKP2SLC6A2SLC6A4CA2ALDH1A1 | |
| SCHEMBL27907763 | 0.82 | SKP2 (0.56) | SKP2SLC6A2SLC6A4CA2ALDH1A1 | |
| SCHEMBL19834227 | 0.81 | BCHE (0.46) | BACE1CA2CYP4A11CYP4F2BCHE | |
| SCHEMBL9309388 | 0.81 | SKP2 (0.48) | SKP2BACE1CA2ALDH1A1POLB | |
| SCHEMBL11855440 | 0.79 | BACE1 (0.46) | SKP2BACE1SLC6A2SLC6A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3312179-B1 | FUSED-RING OR TRICYCLIC ARYL PYRIMIDINE COMPOUND USED AS KINASE INHIBITOR | NANJING SANHOME PHARMACEUTICAL CO LTD (CN) | 2019-07-10 | — | — | EP | disclosed |