⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10032043 | 0.75 | — | — | |
| SCHEMBL13078382 | 0.75 | CYP2C19 (0.45) | — | |
| SCHEMBL860556 | 0.75 | — | — | |
| SCHEMBL12744801 | 0.73 | — | — | |
| SCHEMBL19990 | 0.72 | — | — | |
| SCHEMBL6662230 | 0.71 | — | — | |
| SCHEMBL18757538 | 0.71 | TP53 (0.32) | — | |
| SCHEMBL13078399 | 0.71 | CYP2C19 (0.63) | — | |
| SCHEMBL14446716 | 0.71 | CYP2C19 (0.60) | — | |
| SCHEMBL15235858 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10702504-B2 | Degradation of tripartite motif-containing protein 24 (TRIM24) by conjugation of TRIM24 inhibitors with E3 ligase ligand and methods of use | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2020-07-07 | — | — | US | disclosed |
| US-20190209535-A1 | DEGRADATION OF TRIPARTITE MOTIF-CONTAINING PROTEIN 24 (TRIM24) BY CONJUGATION OF TRIM24 INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | DANA-FARBER CANCER INSTITUTE, INC. | 2019-07-11 | — | — | US | disclosed |